Circassia’s marketed and pipeline products target asthma, chronic obstructive pulmonary disease (COPD) and allergies, and consequently have significant commercial potential.
NIOX® asthma management
Asthma represents one of the largest healthcare burdens. In the US alone, there are 25 million asthmatics, with the medical cost of asthma estimated to account for over $50 billion in 2007. Worldwide, asthma affects 235 million people and is the most frequent chronic disease among children. As a result, our marketed NIOX® products have a major commercial opportunity, and estimates suggest the potential specialist market in the US alone approaches $200 million per year.
Flixotide® / Flovent® substitute
Circassia’s product targets substitution of GSK’s Flixotide®/Flovent® pMDI, which generated global sales of approximately $820 million in 2015. Due to the formulation challenges associated with inhaled respiratory medicines, and relatively limited competition in the pMDI market segment, our particle-engineered products have a major commercial opportunity.
Seretide® / Advair® substitute market
Our Seriveo® product contains fluticasone propionate and salmeterol xinafoate. These are the active components in GSK’s Seretide® / Advair® combination therapy, which generated global sales of approximately $1.5 billion in pMDI in 2015. The complexity of producing a directly substitutable version of Seretide® / Advair® using traditional manufacturing technology, the rigorous standards required for approval and the limited competition in the pMDI market segment present a major opportunity for Circassia’s Seriveo®.
COPD is a major health burden. The World Health Organization estimates that approximately 65 million people worldwide have moderate-to-severe COPD and it is predicted to become the third leading cause of death by 2030.
Circassia’s product contains tiotropium bromide, the active component in Boehringer Ingelheim’s dry powder treatment Spiriva® Handihaler®. Spiriva® is also available as an inhalation spray and is approved in a number of countries, including the US. The product accounted for total revenues of $3.9 billion in 2015.
Novel LABA / LAMA formulation & novel COPD therapy formulation
Circassia’s two novel formulations of currently approved drugs target an underserved segment of the specialist moderate-to-severe COPD market.
- The first contains a LABA / LAMA fixed dose combination. Third-party research suggests the product targets a patient population of up to 350,000 in the US and EU5 with a potential peak sales opportunity of up to $700 million.
- The second targets reductions in COPD exacerbations. The US / EU5 target patient population totals up to 200,000 and market research indicates the product has a potential peak sales opportunity of up to $250 million.
Allergies are extremely common, with allergic rhinitis affecting an estimated 10 – 20% of the world’s population. As a result, over 1 billion people are affected by allergic diseases, and the number is predicted to grow substantially. In the United States, allergic rhinitis affects approximately 50 million people, resulting in over 10 million visits to the physician’s office each year. Circassia’s pipeline products target a number of allergies, including cat, house dust mite, grass and ragweed, which affect millions of people around the world representing a significant market opportunity.
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